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India Issues Urgent GLP-1 Drug Safety Alert The Indian Pharmacopoeia Commission (IPC) has issued a public notice on 14 May calling on doctors, patients, and consumers to closely monitor and report any adverse reactions linked to semaglutide and other GLP-1 receptor agonists including dulaglutide, liraglutide, and tirzepatide

Based on this review, evidence from head-to-head and insulin-comparator trials demonstrates that dual GIP/GLP-1 co-agonism consistently overcomes metabolic plateaus that result from single-pathway therapy, producing superior glycated hemoglobin reduction, bariatric-level weight loss (up to 25.3%), and robust macrovascular and heart failure protection, including a 38% reduction in composite cardiovascular risk among patients with heart failure with preserved ejection fraction (HFpEF)

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Demand for these kinds of drugs has skyrocketed in recent years but the price is a sticking point for many.

Metabolic alterations have been studied in the myocardium of heart failure (HF) patients