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A validated direct anti-inflammatory mechanism in joint tissue could eventually support prescribing to normal-weight arthritis patients a population that represents a substantial portion of those living with rheumatoid arthritis and spondyloarthritis globally, and one that currently has no clinical basis for GLP-1 access

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Jan 16, 2026 Articles, Nephrology, Top Articles, Type 2 Diabetes, Type 2 Diabetes 1,840 views Managing type 2 diabetes in people with advanced chronic kidney disease (CKD) and end-stage kidney disease (ESKD) on dialysis presents unique clinical challenges

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Research shows GLP-1 medications do not inherently preserve muscle, unlike caloric restriction combined with strength training

Physiological Basis Of Exercise Tolerance Causes Of Reduced Exercise Tolerance Exercise Testing and Clinical Assessment Improving Exercise Tolerance Clinical Significance References Further Reading Exercise tolerance captures how efficiently the body delivers and utilizes oxygen during physical activity, making it a powerful indicator of functional capacity, disease burden, and response to rehabilitation