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Patient Self-Monitoring and Red Flag Symptoms Patients should be educated to recognize and report concerning symptoms promptly: Chest pain or pressure, especially with exertion Severe or persistent palpitations Unexplained shortness of breath Syncope (fainting) or near-syncope New or worsening leg swelling Persistent dizziness or lightheadedness Home blood pressure and heart rate monitoring may be beneficial for patients with hypertension or those experiencing symptoms

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Consider using the TSA Cares helpline (855-787-2227) or carrying a TSA Notification Card to facilitate screening

This shift happens because tirzepatide activates GIP and GLP-1 receptors that slow gastric emptying and enhance satiety signals

Tirzepatide tends to be better tolerated in this group

However, its dual action and superior efficacy in glycemic and weight control differentiate it