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Animal studies have shown fetal growth abnormalities and skeletal malformations at clinically relevant doses, though these findings don't always predict human outcomes

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For estimation for this estimand, the intercurrent events and resulting missing values were handled by a hybrid approach using retrieved dropouts imputation from the same treatment group or using all nonmissing data assuming missing at random

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Retrieved from Wharton, S., Blevins, T., Connery, L., et al

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