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Mass General Brigham

Less common concerns include gallstones, a small rise in pancreatitis risk, semaglutide muscle loss during rapid weight loss, and cosmetic effects such as hair loss and facial volume loss (sometimes called Ozempic face)

These medications target glucose metabolism and appetite pathways, not the neuroinflammatory mechanisms typically involved in fibromyalgia pathophysiology

These insights help personalize your dosing strategy and predict which patients may benefit most from treatment acceleration or alternative formulations

However, introducing GLP-1 requires careful consideration of timing, individual readiness, and long-term goals

DOI: 10.1016/j.cmet.2008.11.002