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If stored improperlysuch as at room temperature or in freezing conditionsthe medication may lose potency or develop physical changes visible as discoloration or particle formation

The main adverse effects leading to drug discontinuation were gastrointestinal disorders

In conclusion, tirzepatide increased blood pressure and sympathetic activity in hypertensive rats without cardiac protection, highlighting context-dependent cardiovascular actions

438,439 GLP-1 can also enhance endothelial function by promoting the production of NO, possibly through activating eNOS, thereby affecting vasodilation, anti-inflammatory actions, and anti-atherosclerosis
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