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Most groups reflected the following four themes: (1) comparisons of weight loss efficacy with other treatments, supplements, and different GLP-1 RAs

By activating GLP-1 receptors in the hypothalamus and brainstem, these analogs promote satiety, leading to reduced food intake and weight loss ( Studies as Network Meta-analysis and clinical trials have shown that GLP1-RA can achieve a statistically significant decrease in HbA1C compared to placebo, as well as a weight reduction ranging between 1.3 and 8.65 kg ( With regard to cardioprotection, several mechanisms have been proposed

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Genetic alterations of DPP4 and predisposition to T2DM-associated diseases There are only few studies aiming to identify modifications in the DPP4 gene and their association with T2DM

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