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A substantial body of evidence suggests that both peripheral innate immune cells (such as neutrophils, macrophages, and natural killer cells) and adaptive immune cells (like T cells and B cells) are present in the cellular infiltration of the cerebral embolism area

Drug companies developed the synthetic agonist, which helps the naturally occurring GLP-1 hormone bind to its receptor in the blood and stay in circulation longer

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While broad-spectrum inhibitors (e.g., Batimastat) failed due to dose-limiting musculoskeletal toxicities, highly selective agents like Andecaliximab (targeting MMP-9) offer a more precise alternative

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