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However, there was no such protective effect at lower dose of metformin (0.1 mmol/L) or liraglutide (3 and 10 nmol/L) (Fig

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The AAPS PharmSciTech finding is the kind of formulation result that precedes rather than predicts clinical translation

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While the systemic biological effects of semaglutide that indirectly benefit MASLD/MASH are robustly validated, a knowledge gap persists concerning the drug's direct effects on the liver, alongside the scientific controversy surrounding the gene and protein expression of GLP1 receptor (GLP1R) in the liver [12]