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Colitis was induced by 3% (wt/vol) DSS (3650 kDa, MP Biomedicals, Solon, OH) supplemented in drinking water for 7 days

AMPK = adenosine monophosphate-activated protein kinase

analysis [37], patients on GLP-1 RAs (exenatide, lixisenatide, semaglutide, dulaglutide, liraglutide, tirzepatide) had a significantly lower 1-year shunt placement rate (OR 0.375, 95% CI 0.1710.753, p = 0.047)

10.1172/JCI116186 129 NESINA (2013)

Slower digestion, reduced fluid intake, and changes in gut movement all work together to increase the risk of constipation