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Description
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Among patients with pre-existing substance use disorder, GLP-1s were tied to fewer hospitalizations, overdoses and deaths related to substance use
Important context: the FDA has warned that retatrutide is not a component of an FDA-approved drug and has not been found safe/effective for any condition
What Are GLP-1 Drugs
A peer-reviewed 2026 review mapped the pediatric GLP-1 trial data
The molecule has a Gly8 to Ala substitution in both copies of the GLP-1 analogs to improve resistance to DPP-4 degradation
