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In healthy individuals, studies indicate that the effects of these two hormones are additive (48, 54)

Islet GLP-1 production is also mediated by the cytokine IL-6, which is released in response to exercise, obesity and diabetes [163,164]

Prevention or delay of type 2 diabetes: standards of medical care in diabetes2018

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In one 2024 study, high levels of glucose and triglycerides and low levels of high-density lipoproteinwhich are usually signs of worse metabolic healthwere associated with future risk of depression and anxiety ( JAMA Network Open , DOI: 10.1001/jamanetworkopen.2024.4525)

With increasing frequency over the past few years, optometrists across the country have gotten referrals from internists requesting baseline diabetic retinopathy (DR) screenings for patients about to start therapy with one of the glucagon-like peptide-1 (GLP-1)/glucose-dependent insulinotropic polypeptide (GIP) receptor agonists such as semaglutide (Ozempic, Novo Nordisk), tirzepatide (Mounjaro, Eli Lilly) and dulaglutide (Trulicity, Eli Lilly
