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caloric restriction during growth periods can affect final adult height, and whether orforglipron's appetite-suppressing effects would impair normal growth trajectories requires dedicated study

an analysis based on the current literature

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doi: 10.1016/S0140-6736(21)00213-0 234 WildingJPHBatterhamRLCalannaSDaviesMVan GaalLFLingvayIet al

Importantly, it also involves the braingutimmunepain axis , a bidirectional network through which the central nervous system, gut, immune cells, and peripheral nerves communicate

In rats, induction of gut glucagon-like immunoreactivity induced by either lipids or by physiological concentrations of GIP can be blocked by subdiaphragmatic vagotomy, suggesting that in rats GIP regulation of GLP-1 secretion requires either afferent or efferent signal transmission via the vagus [327]