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The Centers for Disease Control and Prevention estimates over 30 million Americans currently have diabetes, with the condition's economic burden in the US exceeding US$ 327 Bn annually

This is metabolically advantageous during weight loss because it preserves lean mass while preferentially mobilizing adipose tissue
During GLP-1RA therapy, sustained hypophagia may further reduce effective micronutrient intake without immediately producing overt deficiency
In the case of CCI, median and 10 th -90 th percentile were presented rather than median and IQR, as we expected a large majority of all subjects to have CCI values of 0 or 1

Notably, SCFA-mediated GLP-1 release was abolished in Gpr43 -deficient mice, confirming receptor dependency (Psichas et al., 2015)

Intermittent fasting
