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see ESM Methods for details)

For a deeper exploration of this comparison, TRT Nations blog post The Most Effective GLP-1/GIP Weight Loss therapies provides additional clinical context and guidance

Retatrutide injections at higher maintenance doses (8-12 mg) may involve larger injection volumes depending on reconstitution concentration

The PRISMA 2020 guidelines [17] were followed for the correct reporting of this systematic review

In the U.K., Mounjaro is not yet recommended due to lack of sufficient evidence on efficacy and cost-effectiveness

The rising global burden of MASLD and other metabolic diseases (2000-2021)