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Moreover, semaglutide can stimulate the browning of subcutaneous fat adipocytes in obese mice [66], a process that could participate in the putative increase in thermogenesis induced by semaglutide in malnourished mice

Wegovy remains the flagship injectable semaglutide, administered once weekly via a convenient pre-filled pen

GLP-1 specifically inhibits glucagon secretion, which is especially advantageous for individuals with type-2 diabetes (T2DM) who often have increased glucagon levels

These data also highlight the unmet need for, and importance of, examining proteomic changes in response to weight loss pharmacotherapy in future trials

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