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3 Activation of the GLP-1 receptor (GLP-1R) by GLP-1 stimulates insulin release and inhibits glucagon secretion in a glucose-dependent manner

The retatrutide versus semaglutide comparison highlights just how much more aggressive the weight loss trajectory may be, which could have implications for how aggressively providers prescribe to patients at lower BMI ranges

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Increasing GLP-1 in the postprandial period correlates with the increase in blood flow in brain areas related to satiety, such as the hypothalamus and areas of the prefrontal cortex [53]

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In contrast, leaky gut, low-grade inflammation, or dysbiosis may impair GLP-1 secretion and function