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The available human data is smaller than for older peptides because MOTS-c is a relatively recent therapeutic

Secreted frizzled-related protein 4 reduces insulin secretion and is overexpressed in type 2 diabetes

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Reference: [1]Huang, KP., Acosta, A.A., Ghidewon, M.Y

Seventh, we were not able to examine the importance of duration of exposure in the analyses, as the relative rarity of NAION would decrease the statistical power of the study considerably and also violate the General Data Protection Regulations that individualized patients should not be identifiable in register-based studies