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The survival benefit was more pronounced in younger people and those with cardiometabolic comorbidities, highlighting the need for a careful riskbenefit evaluation when prescribing GLP-1 RAs in high-risk individuals.

And the exercise interaction backs this up: higher fitness builds a greater parasympathetic reserve (essentially, a better ability to slow your heart rate), which helps offset the sympathetic drive from GLP-1

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Taking your mind off your symptoms, particularly through doing something creative, can reduce your anxiety and risk of triggering symptoms