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However, the rapid inactivation of GLP-1 by DPP-4 in vivo limits its application in clinic

Despite the limitations of the single-blind design in this clinical study, the advantages in exenatide-treated group in both cognitive and motor functions persisted in the follow-up study after a 12-mo wash-out period. 99 This suggests disease-modifying effects of exenatide, and the results are encouraging enough that a subsequent double-blind clinical study (NCT01971242) was initiated by the same investigators using a sustained release formulation of exenatide ( Bydureon : 2 mg administered subcutaneously once weekly) to evaluate in a similar group of PD subjects over a similar duration of time
[DOI] [PMC free article] [PubMed] [Google Scholar] [31].Wang Y, Wei W, Guo H, et al

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Assess your response for 1 to 2 weeks before deciding if the new dose is tolerable

However, they can be bothersome for some users, prompting them to seek alternative treatments or adjustments in their dosage
