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His concerns were the gaunt appearance and premature ageing, which developed progressively during the course of therapy

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In one clinical trial, 5 mg per week tirzepatide was slightly more effective than 1 mg per week semaglutide in reducing body weight and glycated hemoglobin (HbA1c)

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Author Contributions HJT led the guidelines from funding, engaging partners, coordinating processes, prioritizing clinical questions, co-chairing guideline meetings, coordinating peer review responses and leading writing, approval and publication processes