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GLP-1 receptor agonists show potential anti-inflammatory mechanisms, but evidence for rheumatoid arthritis benefit remains limited

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After a 4-week run-in period in which participants were treated with diet and exercise alone, those who fulfilled the randomisation criteria were randomised (1:1:1:1) using a web-based randomisation system to receive once-daily oral semaglutide 3 mg, 7 mg or 14 mg or placebo for 26 weeks (using a 4-week dose-escalation regimen for the higher doses)

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monitoring protocol, symptom timeline, safe restart criteria.

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