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It works by: Enhancing insulin secretion in a glucose-dependent manner, which helps lower blood sugar without causing hypoglycemia when used alone Suppressing glucagon release from the pancreas, reducing hepatic glucose production Slowing gastric emptying , which prolongs satiety and reduces appetite Acting on central appetite centers in the hypothalamus to decrease food intake Semaglutide is administered subcutaneously (Ozempic, Wegovy) or orally (Rybelsus) and is primarily eliminated via proteolytic degradation, not through hepatic cytochrome P450 enzymes

doi: 10.1038/s41575-019-0158-2 82 SinghSChangHYRichardsTMWeinerJPClarkJMSegalJB

Hypothalamic brain-derived neurotrophic factor regulates glucagon secretion mediated by pancreatic efferent nerves

Why Can GLP-1 RAs Cause Nutritional Deficiencies

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Wang, T