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GLP-1 receptor agonists bind to GLP-1 receptors on pancreatic beta cells, stimulating glucose-dependent insulin secretion whilst simultaneously suppressing glucagon release from alpha cells

They can be very effective, but they also need careful monitoring

Compared to the active state, ECL1 moves toward helix I by 5 when measured at the N-terminal tip of the helix (C of Q211), and ECL1 residue W214 is reoriented ~180 o from an outside-facing position to a position pointing towards helix I

Its a string of amino acids and folds up in a very particular three-dimensional shape like a key for the lock of the receptor

Hundal RS, Inzucchi SE

In recent years, microdosing taking smaller doses than whats generally prescribed for obesity and diabetes has also cultivated a cult-like following online