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Compared with originator, follow-on injectable semaglutide DSs and DPs had new impurities and impurity patterns, including high molecular weight proteins, trace metals, anions, counterions, and residual solvents

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Increasing reports of severe side effects from users of GLP-1 agonist drugs, like Trulicity, have likely driven this rise in cases

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This short half-life made therapeutic use challenging for decades, until researchers began developing GIP receptor agonists and dual/triple agonists that could resist degradation or mimic its effects more efficiently