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Not a single randomized controlled trial evaluated whether sublingual tirzepatide achieved therapeutic blood levels, produced meaningful weight loss, or had an acceptable safety profile

Versus semaglutide, tirzepatide 10 and 15 mg were associated with numerically greater decreases in SBP (mmHg) and diastolic blood pressure (DBP, mmHg) (Table 2)

Each appears in roughly 1% or less of trial participants but needs prompt evaluation if symptoms develop

Blood pressure dropped

A 30-gauge needle is noticeably more comfortable than a 25-gauge needle

If patients experience intolerable side effects during dose escalation, healthcare providers may consider delaying the increase for an additional four weeks or maintaining the current dose if therapeutic goals are being met