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In a separate 36-week phase 2 trial in 281 T2D patients treated with up to 12mg retatrutide weekly, researchers observed significant reductions in HbA1c

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Muscle tissue is metabolically active, and preserving it is critical to maintaining metabolic rate and functional strength

Some potential side effects include nausea and vomiting, diarrhea, constipation, general abdominal discomfort, hypoglycemia, and injection site reactions such as redness

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Week 1 During the first week, some individuals notice subtle changes in appetite