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The Missing Pathway - Amylin Satiety Retatrutide hits three receptors, but not amylin

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The peptide ligand-bound crystal structures of the ECDs of class B GPCRs (including GLP-1 and exendin-4bound GLP-1R, GIP-bound GIPR, and antibody-bound GCGR) do not provide information about the molecular interactions between the receptor and the flexible N-terminal region of peptide ligands

Shi Q, Nong K, Vandvik PO et al (2023) Benefits and harms of drug treatment for type 2 diabetes: systematic review and network meta-analysis of randomised controlled trials