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Taken together, the data in the literature indicate that GLP-1R signaling in ARC may be a major contributor to the homeostatic effects of GLP-1 analogs on feeding, whereas other brain regions such as the brainstem may play a minor role

Diabetes Care (2016) 39:35362

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This has sparked interest in newer metabolic therapies like GLP1 receptor agonists, especially in the context of managing PCOS-related metabolic issues

Effects of chronic glucagon-like peptide-2 therapy during weaning in neonatal pigs