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A thorough history, physical examination, and appropriate investigationswhich may include blood tests, FIT, or endoscopic proceduresare essential to establish the underlying cause and ensure patient safety

As a result, even in the presence of suboptimal glycemic response, patients with an APOE 4 background may still derive substantial cardiometabolic benefit from tirzepatide
& Fan, Z

Tirzepatide is known as a dual GIP and GLP-1 receptor agonist

Tirzepatide versus retatrutide Retatrutide is the emerging triple agonist, targeting GIP, GLP-1, and glucagon receptors

This sparked the idea that GLP-1 analogs with enhanced stability could be developed as potential treatments for type 2 diabetes