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Nausea was more frequent with tirzepatide vs placebo, especially with tirzepatide 15 mg (OR 5.60 [95% CI 3.12, 10.06]), associated with higher incidence of vomiting (OR 5.50 [95% CI 2.40, 12.59]) and diarrhoea (OR 3.31 [95% CI 1.40, 7.85])

Estrogen is a steroid hormone with beneficial effects in the control of energy balance (Brown and Clegg, 2013

Alarming reports published in 2011 (65) led to widely discussed safety concerns, which transiently limited the use of GLP-1RAs for the treatment of T2D

Tirzepatide might have a beneficial impact on many of these pathophysiological mechanisms (Fig

In excess amounts of hydrogen peroxide (H 2 O 2 ), DNA, RNA, and lipids are severely damaged