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Tirzepatide May Be a Lifelong Drug If you stop the medication, you regain the weight theres no question that will happen, says coauthor Louis Aronne, MD, a professor of metabolic research and director of the Center for Weight Management and Metabolic Clinical Research at Weill Cornell Medicine in New York City

Further, the percentage of participants achieving a weight reduction of 5% or more was higher in the tirzepatide groups (85%, 89%, and 91% at 5mg, 10mg, and 15mg, respectively) compared to placebo (35%) [8]