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Unlike peptides that activate only GLP-1 or GIP receptorssuch as sema and tirzRetas activation of the glucagon pathway appears to sustain energy output, even during calorie restriction

2016;311(5):E80317

doi: 10.2174/157339508784325046 40 AschenSZampellJCElhadadSWeitmanEAndrade Brot DeMMehraraBJ

Cardiovascular, mortality, and kidney outcomes with GLP-1 receptor agonists in patients with type 2 diabetes: a systematic review and meta-analysis of cardiovascular outcome trials