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Human EMR data The population of semaglutide and tirzepatide users was selected according to Rodriguez et al., 2024 and a data snapshot created 1/27/2025

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However, emerging lawsuits claim the drug caused an eye condition called non-arteritic anterior ischemic optic neuropathy NAION

A multidisciplinary expert consensus published in Frontiers in Endocrinology recommends starting with osmotic laxatives (MiraLAX or magnesium) and only escalating to stimulant laxatives if osmotic options prove insufficient after 2-3 weeks of consistent use