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And then I think she thought, 'Hey, wait a second, maybe I'll try to go back and play competitive tennis.'" McEnroe points to the World Anti-Doping Organization announcing it was studying GLP-1s to see if athletes were abusing it, which is why so many people are drawn to Williams' story

DURATION-1 Study Group

We're literally just trying to get to a place of negative energy balance, and the GLP-1 is essentially an assist for doing that

The degree of this effect varies widely between patients

Regarding lipid abnormalities, 12 months of metreleptin therapy significantly reduced HbA1c, triglycerides, and liver volume in individuals with GL and PL, with greater benefits observed in GL than in PL (63, 64)