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Plates were incubated at RT for 60 min before measuring the fluorescence intensity at 620 nm and 650 nm by an EnVision multilabel plate reader (PerkinElmer, Boston, USA)

Of particular interest, the discovery of GLP-1 receptor expression in the myocardium and in the vascular endothelium suggested possible roles of GLP-1 in the cardiovascular system and multiple preclinical studies support cardioprotective effects of native GLP-1 (Fig

26(Supplement_1):i127-i130

While these medicines are generally safe, many people have reported some side effects 1 , especially during the early stages of treatment 2

References WeGovy Label: accessdata.fda.gov/ JAMA Network Open Study: jamanetwork.com National Library of Medicine: pmc.ncbi.nlm.nih.gov Journal of Clinical Endocrinology & Metabolism : academic.oup.com University of Colorado Anschutz Medical Campus Study: medschool.cuanschutz.edu Health.com Study: health.com FDA Documentation: fda.gov JBMR Plus: academic.oup.com/jbmrplus Harvard University: health.harvard.edu

Even though excretion in human milk is probably low, renal effects on the offspring cannot be excluded when using SGLT2 inhibitors during lactation, as full functional maturation of the kidney may take 2 years in humans (72)