does semaglutide affect metabolism How Wegovy Work for Weight Loss? The multifaceted effects of semaglutide:

And the two are not always mutually exclusive

Glucagon signalling in hepatocytes suppresses intermediaries in fatty acid synthesis and prompts catabolism of FFAs, leading them to beta-oxidation and degradation, thereby diverting them from storage as triglycerides and eventual release in the form of VLDL [72]

This gives you a starting point so you can actually measure how much a future treatment helps

Possible effects on energy balance and body composition: Some data suggest modest improvements in energy expenditure and preferential loss of fat mass versus lean mass, but appetite suppression is the dominant driver of weight loss

Each increase brings a mini adjustment period

How can the PlexusDx genetic test help prevent weight regain