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Zhang, Q., Xiao, X., Li, M., Li, W., Yu, M., Zhang, H., et al

GLP-1 modulates hepatic lipolysis Lipolysis is the process of converting TG into glycerol and fatty acids under the action of hydrolase, such as adipose triacylglyceride lipase (ATGL), hormone-sensitive lipase (HSL), and monacylglycerol lipase, in which fatty acids can provide energy for the body through -oxidation or other oxidation pathways

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By pre-treating rats with the non-specific cholinergic receptor antagonist atropine as well as the specific M3 cholinergic receptor antagonist 4-DAMP and performing vagotomy, the researchers found that atropine and 4-DAMP significantly reduced metformin-induced GLP-1 secretion, whereas vagotomy had no effect on metformin-induced GLP-1 secretion