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A semaglutida e a liraglutida, inclusive, tm aprovao para uso no tratamento da obesidade, mesmo na ausncia de diabetes, graas ao seu impacto significativo na perda ponderal e na melhora dos parmetros metablicos (BURCELIN

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Journal of Pediatric Psychology , 39(8), 809-825

Clinical Evidence for Semaglutide-Naltrexone Combination The strongest evidence for semaglutide plus naltrexone comes from the IMCOSI phase 2b trial (2021), which enrolled 338 patients and found that the combination resulted in approximately 20% body weight loss over 48 weeks, compared to 16% for semaglutide alonea difference that was statistically significant but modest in absolute terms