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Stabilize cardiac membranes (if ECG changes present: peaked T waves, widened QRS, sine wave) Calcium gluconate 10%: 10 mL IV over 25 min Onset: 13 min Duration: 3060 min Protects myocardium, does not lower potassium

Some people taking tirzepatide report increased sensitivity to cold temperatures

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These adaptations position irisin as a promising therapeutic target for preventing metabolic disorders and optimizing exercise protocols