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Triple agonist retatrutide yielded 28.7% weight loss at 68 weeks, besting Zepbounds Phase III data, while also showing benefit in knee osteoarthritis pain.

However, the current literature reveals a lack of in vivo studies on specific GLP-1R agonists such as semaglutide, necessitating further research to elucidate its precise mechanisms and effects, particularly in cancer

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