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Omeprazole affects stomach acid production, while semaglutide acts on GLP-1 receptors throughout your body

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Safety and pharmacokinetics of single and multiple ascending doses of the novel oral human GLP-1 analogue, oral semaglutide

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A randomized-controlled trial from the New England Journal of Medicine found that 2.4mg of semaglutide a week, together with lifestyle adjustments, led to significant weight loss