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Amylins physiological roles include inhibition of glucagon secretion, reduction in food intake, delay in gastric emptying, activation of brown adipose tissue via the sympathetic nervous system, and increased energy expenditure, ultimately leading to decreased blood glucose levels and weight loss [95]

Even if the impact would be bigger than that, I think over a 10-year period, it will be manageable, and we will have adequate lead time to adjust and prepare for any changes that we see. On a more practical note, he said, Obesity rates around the world are very different, and we have one of the lowest exposures since 75% of our sales come from outside of the US and 40% of our sales are in emerging markets [where average BMIs are far lower]

Kaplan-Meier and Weibull analysis to determine time-to-onset trends

Bhardwaj, P., Iyengar, N

Statements Data availability statement The original contributions presented in the study are included in the article/supplementary material