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Pinch the skin at the injection site and insert the needle at a 45-degree angle

Conclusions Patients with T2D starting tirzepatide had greater HbA1c and weight reductions at 12 months post-initiation than those on injectable semaglutide, regardless of previous GLP-1 RA use, consistent with previous clinical trial results.

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Clinical trials assessing GLP-1 RAs for weight loss rarely report facial fat loss as an adverse effect

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