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Referral to a nephrologist may also be needed in some cases

GPs can switch semaglutide injections for tablets or tirzepatide amid shortages Guidance on selecting alternative glucose lowering therapies for patients with type 2 diabetes has been issued in response to ongoing shortages of semaglutide and other glucagon like peptide-1 receptor agonists (GLP-1 RA)

1 The rising global prevalence of atrial fibrillation can be attributed to the aging of the population, increased rates of obesity, and greater accumulation of cardiovascular risk factors and survival with clinical cardiovascular disease

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However, observational studies like this are often considered less reliable than controlled clinical trials, which showed weight regain after discontinuing the drugs

When comparing GLP1-RA to insulin, there was no significant increase in the risk of major congenital malformations, with an adjusted relative risk of 0.95 for infants exposed to GLP1-RA