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People who lose weight rapidly face substantially higher risk than those who lose gradually

[10] [11] Additional safety considerations include caution in patients with severe gastroparesis, gallbladder disease, and a potential risk of diabetic retinopathy complications with rapid glucose improvement (particularly with semaglutide)

Charbonnel B, Karasik A, Liu J, et al

Are there age-related side effects or contraindications with GLP-1 therapy

While some who take them may only see trivial reductions in weight, the majority will see substantial change, with the average weight loss ranging from 14-20% of initial body weight

Biologic agents targeting specific inflammatory pathwaysincluding TNF- inhibitors (adalimumab, etanercept), IL-6 inhibitors (tocilizumab), T-cell costimulation modulators (abatacept), and B-cell depleting agents (rituximab)provide additional options for patients with inadequate response to conventional therapy