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Finally, TRANSCEND-T2D-3 (NCT06297603) will compare retatrutide to placebo over 14 months, in people with inadequately controlled T2D and moderate-or-severe renal impairment on basal insulin

Here's why: Tirzepatide is a biological medication, which means it can degrade if exposed to temperatures outside the recommended range

When compared with Naltrexone/Bupropion, Tirzepatide users show lower rates of cataracts (HR 0.46, 95% CI 0.230.92, p = 0.025) and oculomotor dysfunction (HR 0.31, 95% CI 0.160.60, p = 2.3 10 4 )

The FDA received over 200 adverse event reports from compounded tirzepatide users as of November 2024, including severe abdominal pain, prolonged vomiting, and dehydration requiring medical intervention

Depending on the provider's practice, users may be offered follow-up appointments to assess progress, adjust dosing, or refine behavioral strategies

Most available studies only include people exposed to GLP-1 agonists very early in pregnancy (typically no later than the first trimester)