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PlexusDx breaks down the science behind fluid changes during weight loss treatment

A recent study finds that the active ingredient in Wegovy and Ozempic significantly decreased heavy drinking in patients with obesity and alcohol use disorder

Weight loss goals are now disease-driven, not cosmetic 5% minimum meaningful benefit 10% required for most metabolic conditions 15% often needed for OSA, HFpEF, MASH, and severe obesity Medication choice is guided by comorbidities GLP-1 receptor agonists and dual GIP/GLP-1 agents are prioritized in patients with: Prediabetes & type 2 diabetes ASCVD Heart failure with preserved EF Metabolic liver disease Obstructive sleep apnea Cardiovascular outcomes now matter Semaglutide 2.4 mg demonstrated a significant reduction in major cardiovascular events even in people without diabetes

However, research suggests that a high protein diet and resistance training may help prevent loss of muscle mass during GLP- 1 RA usage

A random-effects model meta-analysis, pooling hazard ratios from previous RCTs, was conducted using R software to inform the predictive model

No clinical evidence demonstrates that GLP-1 receptor agonists (semaglutide, liraglutide, dulaglutide, or tirzepatide) improve symptoms of postural orthostat...