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For example, the nonbenefit for lixisenatide in the ELIXA trial may be partially attributable to its extremely high-risk cohort, where 100% of participants had established CVD and an ACS within the last 180 days [53]

Zhang Y, Yang D, Jia Q, Yan J, An F

Sci Rep 12(1):1567

Additionally, agents capable of positively modulating more than one peptide hormone receptor simultaneously, such as tirzepatide or the recently characterised GL-0001 peptide, could offer an even more exciting avenue to help realise the potential of gut-derived hormones to treat bone disease

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Stucky, E