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Mechanical allodynia was assessed via von Frey filaments (NC12775-99

By applying a reverse translational approach that evaluates compounds with emerging clinical efficacy, we demonstrated that semaglutide, tirzepatide, and retatrutide blunt alcohol interoceptive/subjective effects, potentially clarifying a clinically meaningful mechanism

The metabolic (glucose-transport) arm of insulin signaling largely the PI3K/Akt pathway in muscle and fat is impaired, while the mitogenic and steroidogenic arms remain intact or even amplified

Study 2: SUSTAIN-6 Trial (Diabetes & Cardiovascular Risk) In the SUSTAIN-6 trial, semaglutide significantly reduced the risk of major cardiovascular events including heart attack and stroke in people with type 2 diabetes